Solid phase synthesis of 5,6-disubstituted pyrimidinone and pyrimidindione derivatives
نویسندگان
چکیده
منابع مشابه
Novel pyrimidinone derivatives: synthesis, antitumor and antimicrobial evaluation.
Starting from 6-aryl-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile (4a-d), a series of mono- and dialkyl derivatives 5a-j and 6a, b was synthesized. Hydrazinolysis of 4a, b, d and 5d afforded the hydrazino derivatives 7a-c which were cyclised to give the triazolopyrimidinones 8a-c and the pyrimidotriazinones 9a-c through the reaction with formic acid and chloroacetyl chloride, resp...
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Synthesis of hydroazulene derivatives has been carried out through a ring-enlargement route by using carbene adduct intermediates. The protocol can be applied for the construction of functionalized hydroazulene skeletons as key components of many natural products as well as the core system of novel liquid-crystalline materials.
متن کاملMicrowave Assisted Synthesis of Pyrano [2, 3-d] Pyrimidinone Derivatives
The parent barbituric acid and 2-thiobarbituric acid are convenient starting compounds for the preparation of different fused heterocycles and 5-substituted derivatives which are pharmacologically one of the most important classes of barbituric acid based compounds. The fused compounds of barbituric and thiobarbituric acid 7-(4-aminophenyl)-5-aryl5H-pyrano [2, 3-d] pyrimidinone, 5a-f have been ...
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چکیده پلاتین، فلزی نجیب، پایدار و گران قیمت با خاصیت کاتالیزوری زیاد است که کاربرد های صنعتی فراوانی دارد. کمپلکس های پلاتین(ii) به عنوان دارو های ضد سرطان شناخته شدند و در شیمی درمانی بیماران سرطانی کاربرد دارند. خاصیت کاتالیزوری و عملکرد گزینشی پلاتین مستقیماً به اندازه و- شکل ماده ی پلاتینی بستگی دارد. بعضی از نانو ذرات فلزی در سطح مشترک مایع- مایع سنتز شده اند، اما نانو ساختار های پلاتین ب...
single-step synthesis of multi-component spirobarbiturates using ionic liquids and synthesis of substituted pyridine filled with catalysts supported on solid substrate
in this thesis, a better reaction conditions for the synthesis of spirobarbiturates catalyzed by task-specific ionic liquid (2-hydroxy-n-(2-hydroxyethyl)-n,n-dimethylethanaminium formate), calcium hypochlorite ca(ocl)2 or n-bromosuccinimide (nbs) in the presence of water at room temperature by ultrasonic technique is provided. the design and synthesis of spirocycles is a challenging task becaus...
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ژورنال
عنوان ژورنال: Arkivoc
سال: 2004
ISSN: 1551-7012
DOI: 10.3998/ark.5550190.0005.530